Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28999664 | 0.98 | TP53 (0.41) | TP53HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL27291390 | 0.79 | TP53 (0.42) | TP53NOTUMKDM4EMAPTLMNA | |
| SCHEMBL11027181 | 0.79 | TP53 (0.42) | TP53KDM4EMAPTLMNAALDH1A1 | |
| SCHEMBL44773 | 0.78 | TP53 (0.48) | TP53HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL27762324 | 0.77 | ALOX5 (0.46) | TP53HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL27863048 | 0.77 | CYP1A2 (0.44) | TP53KDM4ELMNAALDH1A1GAA | |
| SCHEMBL27762333 | 0.76 | TP53 (0.47) | TP53KDM4EMAPTALDH1A1MGLL | |
| SCHEMBL28239501 | 0.75 | HTR3E (0.44) | TP53HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL19526881 | 0.74 | ABL1 (0.44) | TP53ADRB1KDM4EMAPTLMNA | |
| SCHEMBL27797488 | 0.72 | MAPT (0.50) | TP53ADRB1MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055418-B1 | PYRAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-02-26 | — | — | EP | claimed |
| CN-101440065-B | Mechanochemical preparation of 1,3,5-triaryl-2-pyrazoline compounds | UNIV ZHEJIANG TECHNOLOGY | 2011-05-25 | — | — | CN | disclosed |
| US-7875644-B2 | tyrosine kinase inhibitors, in particular Met kinase; antitumor agents;1-(Benzo-1,2,5-thiadiazol-5-ylmethylcarbonyl)-3-(2,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole; leukemia, carcinomas | MERCK PATENT GMBH (DE) | 2011-01-25 | — | — | US | disclosed |
| CN-101440065-A | Mechanochemical preparation of 1,3,5-triaryl-2-pyrazoline compounds | UNIV ZHEJIANG TECHNOLOGY (CN) | 2009-05-27 | — | — | CN | disclosed |
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MERCK PATENT GESELLSCHAFT (DE) | 2008-10-09 | — | — | US | disclosed |
| CN-1004272-B | PYRAZOLINE INSECTICIDES | FMC公司 | 1989-05-24 | — | — | CN | disclosed |
| CN-85107882-A | Preparation method for pyrazolines | — | 1986-06-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249095-A1 | 1-Acyldihydropyrazole Derivatives | MET, FLT3, ERBB3 | TP53 295/4885HTR3E 1347/4885HTR3B 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.