Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819125 | 0.84 | HTR2A (0.40) | SLC6A4KDM4ELMNAHTR2AKCNH2 | |
| SCHEMBL9818894 | 0.84 | HTR2A (0.40) | SLC6A4KDM4ELMNAHTR2AKCNH2 | |
| SCHEMBL9819073 | 0.81 | PRKAB2 (0.47) | SLC6A4PPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL13540952 | 0.81 | SLC6A4 (0.43) | SLC6A4PPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL10900497 | 0.79 | SIGMAR1 (0.47) | SLC6A4PPARGPPARA | |
| SCHEMBL15707806 | 0.79 | SLC6A4 (0.43) | SLC6A4PPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL9255317 | 0.78 | ALDH1A1 (0.47) | SLC6A4PPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL23357209 | 0.77 | FFAR1 (0.53) | SLC6A4PPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL9818834 | 0.77 | FFAR1 (0.53) | SLC6A4PPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL28858705 | 0.76 | SLC6A4 (0.44) | SLC6A4PPARGPPARAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0230379-B1 | CHROMAN- AND THIOCHROMAN-4-ACETIC ACIDS USEFUL IN THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4853410-A | Hydroxyacetic acid derivatives for the treatment of diabetic complications | PFIZER INC. (US) | 1989-08-01 | — | — | US | disclosed |
| WO-1987004344-A1 | HYDROXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF DIABETIC COMPLICATIONS | PFIZER INC. (US) | 1987-07-30 | — | — | WO | disclosed |
| EP-0230379-A2 | Chroman- and thiochroman-4-acetic acids useful in the treatment of diabetic complications | PFIZER INC. (US) | 1987-07-29 | — | — | EP | disclosed |