Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.49 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.49 |
| ▸ | TMPRSS4 | Q9NRS4 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CLPP | Q16740 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819107 | 0.89 | GRIK1 (0.50) | GRIK1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL9819165 | 0.83 | RHOC (0.49) | GRIK1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL9818823 | 0.83 | RHOC (0.49) | GRIK1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL9819122 | 0.82 | IDO1 (0.47) | GRIK1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL9818991 | 0.82 | IDO1 (0.49) | GRIK1P2RX1P2RX4P2RX7TMPRSS4 | |
| SCHEMBL9819209 | 0.81 | IDO1 (0.47) | IDO1LMNAMEN1KMT2AMAPT | |
| SCHEMBL9818887 | 0.80 | IDO1 (0.47) | GRIK1IDO1ALDH1A1MEN1KMT2A | |
| SCHEMBL9818928 | 0.79 | EPHX2 (0.50) | IDO1EPHX2 | |
| SCHEMBL9819335 | 0.78 | IDO1 (0.50) | IDO1LMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL9819198 | 0.78 | ENPP3 (0.49) | IDO1LMNASMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5034410-A | Nitrile and oxo containing amides or thioamides | SYNTEX (U.S.A.) INC. (US) | 1991-07-23 | — | — | US | disclosed |