Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6733912 | 0.94 | CA4 (0.43) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL666362 | 0.94 | CA4 (0.43) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL11439786 | 0.94 | CA4 (0.43) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL10887232 | 0.94 | CA4 (0.43) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| Silver SCHEMBL6733904 | 0.94 | CA4 (0.43) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL10887183 | 0.94 | CA4 (0.43) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL4624370 | 0.94 | CA4 (0.50) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| Water SCHEMBL14109824 | 0.91 | CA4 (0.42) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL17961697 | 0.88 | CA4 (0.40) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| SCHEMBL9007172 | 0.82 | CA4 (0.41) | CA4FFAR3HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4200586-A | Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds | PHILLIPS PETROLEUM COMPANY (US) | 1980-04-29 | — | — | US | claimed |
| EP-0103901-B1 | MULTILAYER ANALYTICAL ELEMENT | FUJI PHOTO FILM CO., LTD. (JP) | 1991-12-11 | — | — | EP | disclosed |
| US-4587100-A | PEROXIDDASE ON LIGHT TRANSMISSIVE SUPPORT | FUJI PHOTO FILM CO., LTD. (JP) | 1986-05-06 | — | — | US | disclosed |
| US-4578245-A | 1,2,3-TRI-SUBSTITUTED COMPOUND OF 4-AMINO-3-PYRAZOLINS-5-ONE AS CHROMOGEN | FUJI PHOTO FILM CO., LTD. (JP) | 1986-03-25 | — | — | US | disclosed |
| EP-0103901-A2 | Multilayer analytical element | FUJI PHOTO FILM CO., LTD. (JP) | 1984-03-28 | — | — | EP | disclosed |
| EP-0103288-A1 | Multilayer analytical element | FUJI PHOTO FILM CO., LTD. (JP) | 1984-03-21 | — | — | EP | disclosed |
| EP-0101945-A1 | Multilayer analytical element | FUJI PHOTO FILM CO., LTD. (JP) | 1984-03-07 | — | — | EP | disclosed |
| US-4200586-A | Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds | PHILLIPS PETROLEUM COMPANY (US) | 1980-04-29 | — | — | US | disclosed |