Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | FPR3 | P25089 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819485 | 0.95 | ALDH1A1 (0.42) | ALDH1A1CHRNA4FPR3FPR2POLB | |
| SCHEMBL9819529 | 0.88 | POLB (0.40) | ALDH1A1CHRNA4HDAC1HDAC3POLB | |
| SCHEMBL9819516 | 0.82 | LMNA (0.44) | ALDH1A1HDAC1HDAC3POLBATM | |
| SCHEMBL9819475 | 0.82 | POLB (0.43) | CHRNA4HDAC1HDAC3POLBHDAC6 | |
| SCHEMBL9819432 | 0.79 | LMNA (0.45) | ALDH1A1CHRNA4POLBRAB9AKMT2A | |
| SCHEMBL9819472 | 0.79 | HDAC1 (0.43) | ALDH1A1HDAC1HDAC3POLBHDAC6 | |
| SCHEMBL19746834 | 0.77 | USP30 (0.50) | ALDH1A1HDAC1HDAC3HDAC6RAB9A | |
| SCHEMBL9819468 | 0.77 | LMNA (0.47) | ALDH1A1POLBATM | |
| SCHEMBL9819528 | 0.77 | POLB (0.47) | ALDH1A1CHRNA4HDAC1HDAC3POLB | |
| SCHEMBL9819487 | 0.76 | CYP3A4 (0.54) | ALDH1A1HDAC1HDAC3POLBHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0317588-B1 | ISOXAZOLES WITH NOOTROPIC ACTIVITY | ZAMBON GROUP S.p.A. (IT) | 1991-08-07 | — | — | EP | disclosed |
| US-4985428-A | Isoxazoles with nootropic activity | ZAMBON GROUP S.P.A. (IT) | 1991-01-15 | — | — | US | disclosed |
| EP-0317588-A1 | ISOXAZOLES WITH NOOTROPIC ACTIVITY. | ZAMBON SPA (IT) | 1989-05-31 | — | — | EP | disclosed |
| WO-1988009330-A1 | ISOXAZOLES WITH NOOTROPIC ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 1988-12-01 | — | — | WO | disclosed |