Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TBXAS1 | P24557 | 5/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9819820 | 1.00 | PTAFR (0.70) | PTAFRKDM4EALDH1A1TBXAS1S1PR3 | |
| SCHEMBL9819936 | 0.95 | PTAFR (0.75) | PTAFRKDM4EALDH1A1TBXAS1POLB | |
| Hydrochloric Acid SCHEMBL9819882 | 0.94 | PTAFR (0.73) | PTAFRKDM4EALDH1A1TBXAS1POLB | |
| Fumaric Acid SCHEMBL10651563 | 0.84 | PTAFR (0.65) | PTAFRKDM4EALDH1A1TBXAS1 | |
| Fumaric Acid SCHEMBL29961145 | 0.84 | PTAFR (0.65) | PTAFRKDM4EALDH1A1TBXAS1 | |
| Fumaric Acid SCHEMBL9819910 | 0.84 | PTAFR (0.65) | PTAFRKDM4EALDH1A1TBXAS1 | |
| Fumaric Acid SCHEMBL10651556 | 0.84 | PTAFR (0.65) | PTAFRKDM4EALDH1A1TBXAS1 | |
| Fumaric Acid SCHEMBL9819914 | 0.84 | PTAFR (0.65) | PTAFRKDM4EALDH1A1TBXAS1 | |
| Hydrochloric Acid SCHEMBL9819839 | 0.83 | PTAFR (0.93) | PTAFRKDM4EALDH1A1TBXAS1 | |
| SCHEMBL9819753 | 0.83 | PTAFR (1.00) | PTAFRKDM4EALDH1A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4987132-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |