Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18799257 | 0.86 | ALOX15 (0.36) | ALOX15CISD1BACE1AMY1AGPR35 | |
| SCHEMBL24817709 | 0.80 | IDO1 (0.30) | — | |
| SCHEMBL12722836 | 0.76 | GSK3B (0.35) | ALOX15KDM4EALOX12 | |
| SCHEMBL69493 | 0.73 | ALOX15 (0.50) | ALOX15HSP90AA1ALOX12 | |
| SCHEMBL1005024 | 0.71 | TSHR (0.46) | HSP90AA1 | |
| SCHEMBL9820018 | 0.71 | MAPT (0.42) | ALOX15KDM4EALOX12 | |
| SCHEMBL1001806 | 0.71 | CA3 (0.36) | KDM4E | |
| SCHEMBL13636128 | 0.70 | SRC (0.37) | ALOX15KDM4E | |
| SCHEMBL25704899 | 0.70 | KDM4E (0.34) | KDM4E | |
| SCHEMBL28644250 | 0.70 | ALOX15 (0.44) | ALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210559-B1 | N-ACYLDIHYDRORESORUFIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AS WELL AS THEIR USE FOR THE DETERMINATION OF HYDROGEN PEROXIDE, PEROXIDATICALLY ACTIVE COMPOUNDS, OR PEROXIDASE | Roche Diagnostics GmbH (DE) | 1991-09-25 | — | — | EP | disclosed |
| EP-0156347-B1 | GLYCOSIDES OF RESOFURIN DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE IN THE DETERMINATION OF THE ACTIVITY OF GLYCOSIDASES | Roche Diagnostics GmbH (DE) | 1991-09-04 | — | — | EP | disclosed |
| US-4737466-A | N-acyldihydroresorufin derivatives, processes for their preparation, reagents containing them and the use thereof for determining hydrogen peroxide, peroxidate-acting compounds or peroxidase | BOEHRINGER MANNHEIM GMBH (DE) | 1988-04-12 | — | — | US | disclosed |
| EP-0156347-A2 | Glycosides of resofurin derivatives, method for their preparation and their use in the determination of the activity of glycosidases | Roche Diagnostics GmbH (DE) | 1985-10-02 | — | — | EP | disclosed |