Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.69 |
| ▸ | NPC1 | O15118 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28301495 | 0.82 | RAB9A (1.00) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL30056033 | 0.76 | RAB9A (0.89) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL1259295 | 0.75 | CYP1A2 (1.00) | RAB9ANPC1KMT2AMEN1CYP1A2 | |
| Hydrogen Sulfide SCHEMBL28246712 | 0.74 | CYP1A2 (0.96) | RAB9ANPC1KMT2AMEN1CYP1A2 | |
| SCHEMBL7306947 | 0.73 | CYP1A2 (0.69) | RAB9ANPC1KMT2AMEN1CYP1A2 | |
| SCHEMBL1180922 | 0.72 | NPC1 (1.00) | RAB9ANPC1KMT2AMEN1CYP1A2 | |
| SCHEMBL6241316 | 0.72 | NPC1 (0.65) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL28953063 | 0.72 | NPC1 (0.56) | RAB9ANPC1KMT2AMEN1POLB | |
| SCHEMBL5552160 | 0.72 | APP (0.65) | RAB9ANPC1KMT2AMEN1POLB | |
| Fluoride SCHEMBL28392203 | 0.71 | CYP1A2 (0.67) | RAB9ANPC1KMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248523-B1 | PYRAZOLES | FISONS plc (GB) | 1991-10-16 | — | — | EP | disclosed |
| US-4803216-A | Pyrazole-3-amines as anti-inflammatory agents | FISONS PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| EP-0248523-A1 | Pyrazoles | FISONS plc (GB) | 1987-12-09 | — | — | EP | disclosed |