Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.57 |
| ▸ | EEF2K | O00418 | 1/20 | 0.57 |
| ▸ | PLK4 | O00444 | 1/20 | 0.57 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.57 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | CDK1 | P06493 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | FER | P16591 | 1/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.57 |
| ▸ | CDK2 | P24941 | 1/20 | 0.57 |
| ▸ | MARK3 | P27448 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | FLT3 | P36888 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820109 | 0.85 | RPS6KA3 (0.66) | DYRK1AEEF2KPLK4DAPK3DYRK3 | |
| SCHEMBL6689658 | 0.77 | EGFR (0.70) | DYRK1ACDK1FGFR1PDGFRBDYRK1B | |
| SCHEMBL8020401 | 0.77 | MAPT (0.67) | CDK2KMT2AMEN1MAPTMAPK1 | |
| SCHEMBL12037059 | 0.71 | MAPT (0.71) | GSK3BABCG2KMT2AMEN1MAPT | |
| SCHEMBL2623444 | 0.71 | MAPT (0.71) | GSK3BABCG2KMT2AMEN1MAPT | |
| SCHEMBL4498877 | 0.70 | PRKAB2 (0.57) | CDK1FGFR1CDK2GSK3BHIF1A | |
| SCHEMBL5259065 | 0.70 | MAPK14 (0.61) | DYRK1AEEF2KPLK4DAPK3DYRK3 | |
| SCHEMBL5256323 | 0.70 | PLK4 (0.57) | DYRK1AEEF2KPLK4DAPK3DYRK3 | |
| SCHEMBL6689654 | 0.70 | FGFR1 (0.57) | CDK1FGFR1KDRPDGFRBABCG2 | |
| SCHEMBL316390 | 0.69 | RAB9A (0.81) | KMT2AMEN1MAPTMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248523-B1 | PYRAZOLES | FISONS plc (GB) | 1991-10-16 | — | — | EP | claimed |
| EP-0248523-A1 | Pyrazoles | FISONS plc (GB) | 1987-12-09 | — | — | EP | claimed |
| EP-0248523-B1 | PYRAZOLES | FISONS plc (GB) | 1991-10-16 | — | — | EP | disclosed |
| US-4803216-A | Pyrazole-3-amines as anti-inflammatory agents | FISONS PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| EP-0248523-A1 | Pyrazoles | FISONS plc (GB) | 1987-12-09 | — | — | EP | disclosed |