Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | DHFR | P00374 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18118028 | 0.81 | HAO1 (0.55) | RAB9AMAPTALDH1A1HTTNPC1 | |
| SCHEMBL9820118 | 0.77 | TNIK (0.50) | MAPTGAAALDH1A1HTTL3MBTL1 | |
| SCHEMBL13844997 | 0.77 | MAPK10 (0.46) | RAB9AMAPTALDH1A1NPC1MAPK1 | |
| SCHEMBL23794879 | 0.76 | ROCK1 (0.47) | RAB9AMAPTNPC1RECQLMEN1 | |
| SCHEMBL834683 | 0.76 | MAPT (0.50) | RAB9AMAPTGAAALDH1A1NPC1 | |
| SCHEMBL1272593 | 0.75 | — | — | |
| SCHEMBL1459772 | 0.75 | MAPT (1.00) | RAB9AMAPTGAAALDH1A1HTT | |
| SCHEMBL39057 | 0.75 | MAPT (1.00) | RAB9AMAPTGAAALDH1A1HTT | |
| SCHEMBL9820128 | 0.74 | DHODH (0.60) | RAB9AMAPTGAAALDH1A1HTT | |
| SCHEMBL16881696 | 0.74 | GRM4 (0.53) | RAB9AMAPTGAANPC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248523-B1 | PYRAZOLES | FISONS plc (GB) | 1991-10-16 | — | — | EP | claimed |
| EP-0248523-A1 | Pyrazoles | FISONS plc (GB) | 1987-12-09 | — | — | EP | claimed |
| EP-0248523-B1 | PYRAZOLES | FISONS plc (GB) | 1991-10-16 | — | — | EP | disclosed |
| US-4803216-A | Pyrazole-3-amines as anti-inflammatory agents | FISONS PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| EP-0248523-A1 | Pyrazoles | FISONS plc (GB) | 1987-12-09 | — | — | EP | disclosed |