Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.41 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FER | P16591 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844997 | 0.80 | MAPK10 (0.46) | FLT3CDK2MKNK2STK17AMEN1 | |
| SCHEMBL18118028 | 0.80 | HAO1 (0.55) | DHFRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL834683 | 0.79 | MAPT (0.50) | AURKADHFRCDK1FGFR1RPS6KB1 | |
| SCHEMBL1272593 | 0.78 | — | — | |
| SCHEMBL9820193 | 0.77 | RAB9A (0.61) | DHFRGAAMEN1KMT2AMAPT | |
| SCHEMBL20448349 | 0.76 | MEN1 (0.32) | GAAMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL23794879 | 0.76 | ROCK1 (0.47) | GSK3BROCK1MEN1KMT2AMAPT | |
| SCHEMBL27764418 | 0.76 | AGPAT2 (0.37) | GAAMAPTALDH1A1LMNAHTT | |
| SCHEMBL30732613 | 0.73 | ALOX12 (0.51) | CDK2GSK3BROCK1MEN1KMT2A | |
| SCHEMBL3264551 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0248523-B1 | PYRAZOLES | FISONS plc (GB) | 1991-10-16 | — | — | EP | claimed |
| EP-0248523-A1 | Pyrazoles | FISONS plc (GB) | 1987-12-09 | — | — | EP | claimed |
| EP-0248523-B1 | PYRAZOLES | FISONS plc (GB) | 1991-10-16 | — | — | EP | disclosed |
| US-4803216-A | Pyrazole-3-amines as anti-inflammatory agents | FISONS PLC (GB) | 1989-02-07 | — | — | US | disclosed |
| EP-0248523-A1 | Pyrazoles | FISONS plc (GB) | 1987-12-09 | — | — | EP | disclosed |