Sugi Predict

Sugi Predict / Compounds / SCHEMBL982076

SCHEMBL982076

SCHEMBL982076

COC(=O)c1ccc(C(C)=O)c2ccccc12

nearest known ligand 0.53

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 2/20 0.53
▸ LMNA P02545 5/20 0.52
▸ TSHR P16473 2/20 0.52
▸ NR4A2 P43354 4/20 0.51
▸ CREBBP Q92793 1/20 0.51
▸ KDM4E B2RXH2 6/20 0.50
▸ ALDH1A1 P00352 5/20 0.50
▸ CFTR P13569 1/20 0.50
▸ HSD17B10 Q99714 1/20 0.50
▸ POLB P06746 1/20 0.48
▸ ATM Q13315 1/20 0.48
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.46
▸ PLK1 P53350 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31049726 1.00 BRD4 (0.53) BRD4LMNATSHRNR4A2CREBBP
SCHEMBL31049722 1.00 BRD4 (0.53) BRD4LMNATSHRNR4A2CREBBP
SCHEMBL29434198 0.92 BRD4 (0.59) BRD4LMNATSHRNR4A2CREBBP
SCHEMBL70381 0.92 BRD4 (0.59) BRD4LMNATSHRNR4A2CREBBP
SCHEMBL7841351 0.86 KDM4E (0.46) BRD4LMNATSHRCREBBPKDM4E
SCHEMBL38471077 0.85 KDM4E (0.55) BRD4LMNATSHRCREBBPKDM4E
SCHEMBL10391045 0.85 KDM4E (0.55) BRD4LMNATSHRCREBBPKDM4E
SCHEMBL26312586 0.85 BRD4 (0.50) BRD4LMNATSHRNR4A2CREBBP
SCHEMBL5750893 0.84 BRD4 (0.53) BRD4LMNATSHRNR4A2CREBBP
SCHEMBL70429 0.83 LMNA (0.59) BRD4LMNATSHRNR4A2CREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230195003-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJIFILM BUSINESS INNOVATION CORP. (JP) 2023-06-22 — — US disclosed
US-20230195003-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJIFILM BUSINESS INNOVATION CORP. (JP) 2023-06-22 — — US disclosed
CN-113354530-A Method for preparing 4-acetyl-1-naphthoic acid 东莞市东阳光动物保健药品有限公司 2021-09-07 — — CN disclosed
CN-111333512-A Preparation of Aforana key intermediate 4-acetyl-1-naphthoate 江苏君若药业有限公司 2020-06-26 — — CN disclosed
CN-105646215-B Process for the preparation of 3-trifluoromethyl chalcones 杜邦公司 2020-04-14 — — CN disclosed
US-10160731-B2 Method for preparing 3-trifluoromethyl chalcones E.I. DU PONT DE NEMOURS AND COMPANY (US) 2018-12-25 — — US disclosed
US-20180222873-A1 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES CORTEVA AGRISCIENCE LLC 2018-08-09 — — US disclosed
US-9938248-B2 Method for preparing 3-trifluoromethyl chalcones E.I. DU PONT DE NEMOURS AND COMPANY (US) 2018-04-10 — — US disclosed
US-20180057468-A1 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES CORTEVA AGRISCIENCE LLC 2018-03-01 — — US disclosed
US-9834523-B2 Method for preparing 3-trifluoromethyl chalcones E.I. DU PONT DE NEMOURS AND COMPANY (US) 2017-12-05 — — US disclosed
EP-2181100-A2 INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES Bayer CropScience AG (DE) 2010-05-05 — — EP disclosed
EP-2176244-A2 METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES E. I. du Pont de Nemours and Company (US) 2010-04-21 — — EP disclosed
CN-101652354-A insecticidal aryl isoxazoline derivatives BAYER CROPSCIENCE AG DE 2010-02-17 — — CN disclosed
US-20090318409-A1 PYRROLIDINE INHIBITORS OF IAP GENENTECH, INC. (US) 2009-12-24 — — US disclosed
US-20090318409-A1 PYRROLIDINE INHIBITORS OF IAP GENENTECH, INC. (US) 2009-12-24 — — US disclosed
WO-2009126668-A2 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-10-15 — — WO disclosed
US-20090176822-A1 PYRROLIDINE INHIBITORS OF IAP GENENTECH, INC. (US) 2009-07-09 — — US disclosed
US-20090176822-A1 PYRROLIDINE INHIBITORS OF IAP GENENTECH, INC. (US) 2009-07-09 — — US disclosed
WO-2009025983-A2 METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-02-26 — — WO disclosed
WO-2008122375-A2 INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2008-10-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10160731-B2 Method for preparing 3-trifluoromethyl chalcones NR3C2, CYP4A11, RAE1 BRD4 992/4885LMNA 2654/4885TSHR 1076/4885
US-20090176822-A1 PYRROLIDINE INHIBITORS OF IAP BIRC5, XIAP, BIRC2 BRD4 203/4885LMNA 2663/4885TSHR 3205/4885
US-20180057468-A1 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES NR3C2, CYP4A11, RAE1 BRD4 992/4885LMNA 2654/4885TSHR 1076/4885
US-20180222873-A1 METHOD FOR PREPARING 3-TRIFLUOROMETHYL CHALCONES NR3C2, CYP4A11, RAE1 BRD4 992/4885LMNA 2654/4885TSHR 1076/4885
US-20090318409-A1 PYRROLIDINE INHIBITORS OF IAP BIRC5, XIAP, BIRC2 BRD4 203/4885LMNA 2663/4885TSHR 3205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.