SCHEMBL9821036

SCHEMBL9821036

CC(=O)c1cc(Cl)c(N)c(Cl)c1F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
ALDH1A1 P00352 3/20 0.32
CYP3A4 P08684 2/20 0.32
KDM4E B2RXH2 2/20 0.32
GLA P06280 2/20 0.32
FADS1 O60427 1/20 0.32
NOTUM Q6P988 1/20 0.32
HPGD P15428 1/20 0.32
HSD11B1 P28845 2/20 0.32
SLC9A1 P19634 1/20 0.32
POLB P06746 1/20 0.32
APEX1 P27695 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
ADORA2A P29274 1/20 0.31
MAOA P21397 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27754447 0.83 CYP3A4 (0.44) GAACA1CA2CA9ALDH1A1
SCHEMBL9821019 0.82 GAA (0.33) GAACA1CA2CA9ALDH1A1
SCHEMBL9821187 0.82 GAA (0.35) GAACA1CA2CA9ALDH1A1
SCHEMBL23496738 0.81 GAA (0.51) GAAALDH1A1KDM4EGLAHPGD
SCHEMBL9821037 0.78 TAS1R3 (0.33) GAAALDH1A1KDM4EGLANOTUM
SCHEMBL31726191 0.78 TSHR (0.35) ALDH1A1POLBAPEX1ADORA2AMAOA
SCHEMBL2876064 0.78 GAA (0.36) GAACA1CA2CA9ALDH1A1
SCHEMBL3549755 0.77 CA12 (0.36) GAACA1CA2CA9ALDH1A1
SCHEMBL2719368 0.76 KEAP1 (0.36) GAACA1CA2CA9ALDH1A1
SCHEMBL22342670 0.75 CES2 (0.38) CA1CA2ALDH1A1HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0224001-B1 ANTHRANILONITRILE DERIVATIVES AND RELATED COMPOUNDS AS USEFUL AGENTS FOR PROMOTING GROWTH, IMPROVING FEED EFFICIENCY, AND FOR INCREASING THE LEAN MEAT TO FAT RATIO OF WARM-BLOODED ANIMALS AMERICAN CYANAMID COMPANY (US) 1991-03-20 EP disclosed
US-4863959-A Anthranilonitrile derivatives as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals AMERICAN CYANAMID COMPANY (US) 1989-09-05 US disclosed
EP-0224001-A1 Anthranilonitrile derivatives and related compounds as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals AMERICAN CYANAMID COMPANY (US) 1987-06-03 EP disclosed