SCHEMBL9821187

SCHEMBL9821187

CC(=O)c1cc(Cl)c(N)c(Br)c1F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.35
MAPT P10636 1/20 0.35
POLB P06746 1/20 0.33
APEX1 P27695 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA9 Q16790 2/20 0.33
MAOA P21397 2/20 0.32
MAOB P27338 2/20 0.32
PIM1 P11309 1/20 0.31
ALDH1A1 P00352 4/20 0.31
KDM4E B2RXH2 2/20 0.31
GLA P06280 2/20 0.31
FADS1 O60427 1/20 0.31
NOTUM Q6P988 1/20 0.31
HPGD P15428 1/20 0.31
HSD11B1 P28845 1/20 0.30
CYP3A4 P08684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9821094 0.82 HDAC1 (0.39) MAPTPOLBCA1CA2CA9
SCHEMBL9821036 0.82 GAA (0.33) GAAPOLBAPEX1TDP1L3MBTL1
SCHEMBL9821019 0.79 GAA (0.33) GAAPOLBAPEX1TDP1L3MBTL1
SCHEMBL2876064 0.79 GAA (0.36) GAAMAPTPOLBAPEX1TDP1
SCHEMBL9821037 0.76 TAS1R3 (0.33) GAAMAPTALDH1A1KDM4EGLA
SCHEMBL9928681 0.74 MEN1 (0.36) MAPTPOLBAPEX1MAOAMAOB
SCHEMBL22862294 0.73 ALDH1A1 (0.40) GAAPOLBAPEX1TDP1L3MBTL1
SCHEMBL2719368 0.73 KEAP1 (0.36) GAAMAPTCA1CA2CA9
SCHEMBL1144508 0.73 GAA (0.40) GAAMAPTPOLBCA1CA2
SCHEMBL29947046 0.73 GAA (0.40) GAAMAPTPOLBCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0224001-B1 ANTHRANILONITRILE DERIVATIVES AND RELATED COMPOUNDS AS USEFUL AGENTS FOR PROMOTING GROWTH, IMPROVING FEED EFFICIENCY, AND FOR INCREASING THE LEAN MEAT TO FAT RATIO OF WARM-BLOODED ANIMALS AMERICAN CYANAMID COMPANY (US) 1991-03-20 EP disclosed
US-4863959-A Anthranilonitrile derivatives as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals AMERICAN CYANAMID COMPANY (US) 1989-09-05 US disclosed
EP-0224001-A1 Anthranilonitrile derivatives and related compounds as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals AMERICAN CYANAMID COMPANY (US) 1987-06-03 EP disclosed