SCHEMBL9821071

SCHEMBL9821071

CC(=O)Nc1ccc(C(=O)C(C)F)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
HTT P42858 1/20 0.53
ALDH1A1 P00352 4/20 0.53
MEN1 O00255 4/20 0.52
KMT2A Q03164 4/20 0.52
CA12 O43570 2/20 0.52
CA1 P00915 2/20 0.52
CA2 P00918 2/20 0.52
CA9 Q16790 2/20 0.52
TDP1 Q9NUW8 1/20 0.52
BRD4 O60885 1/20 0.52
NR1I2 O75469 1/20 0.52
MB P02144 1/20 0.52
CYP1A1 P04798 1/20 0.52
CA3 P07451 1/20 0.52
CYP3A4 P08684 1/20 0.52
MAPT P10636 1/20 0.52
RARG P13631 1/20 0.52
TSHR P16473 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15047897 0.85 SMN1; SMN2 (0.57) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
SCHEMBL11235456 0.83 SMN1; SMN2 (0.55) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
SCHEMBL10815283 0.81 SMN1; SMN2 (0.53) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
SCHEMBL15598698 0.81 SMN1; SMN2 (0.53) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
SCHEMBL4051682 0.81 ALDH1A1 (0.56) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
SCHEMBL6209273 0.81 LMNA (0.54) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
SCHEMBL10701976 0.80 SMN1; SMN2 (0.52) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
SCHEMBL10956775 0.80 ALDH1A1 (0.56) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
SCHEMBL4049279 0.79 MEN1 (0.56) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1
Hydrochloric Acid SCHEMBL9596558 0.79 ALDH1A1 (0.50) SMN1; SMN2L3MBTL1HTTALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0224001-B1 ANTHRANILONITRILE DERIVATIVES AND RELATED COMPOUNDS AS USEFUL AGENTS FOR PROMOTING GROWTH, IMPROVING FEED EFFICIENCY, AND FOR INCREASING THE LEAN MEAT TO FAT RATIO OF WARM-BLOODED ANIMALS AMERICAN CYANAMID COMPANY (US) 1991-03-20 EP disclosed
US-4863959-A Anthranilonitrile derivatives as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals AMERICAN CYANAMID COMPANY (US) 1989-09-05 US disclosed
EP-0224001-A1 Anthranilonitrile derivatives and related compounds as useful agents for promoting growth, improving feed efficiency, and for increasing the lean meat to fat ratio of warm-blooded animals AMERICAN CYANAMID COMPANY (US) 1987-06-03 EP disclosed