Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9820961 | 0.82 | TSHR (0.34) | LMNATYRTSHRSLC6A2SLC6A4 | |
| SCHEMBL1981841 | 0.81 | HTR2A (0.40) | LMNATYRTSHRSLC6A2SLC6A4 | |
| SCHEMBL17346807 | 0.78 | GAA (0.37) | TSHRNPC1POLB | |
| SCHEMBL15559251 | 0.78 | GAA (0.37) | TSHRNPC1POLB | |
| SCHEMBL16841701 | 0.77 | ABCB1 (0.43) | SLC6A4MAPTALDH1A1 | |
| SCHEMBL6322965 | 0.75 | ALDH1A1 (0.41) | LMNASMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL18906100 | 0.72 | ALDH1A1 (0.43) | LMNATSHRSMN1; SMN2NPC1MAPT | |
| SCHEMBL4327374 | 0.72 | KDM1A (0.41) | LMNATYRTSHRSLC6A2SLC6A4 | |
| SCHEMBL9820910 | 0.71 | SIGMAR1 (0.47) | SMN1; SMN2NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL18906099 | 0.71 | CA2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0188887-B1 | TERTIARY AMINE COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-05-02 | — | — | EP | disclosed |
| EP-0188887-A1 | Tertiary amine compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-07-30 | — | — | EP | disclosed |