Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.35 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9821722 | 0.82 | LTB4R (0.35) | AKT1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL9821761 | 0.80 | AKT1 (0.38) | AKT1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL10504909 | 0.80 | ESR1 (0.34) | AKT1KDM4EALDH1A1GAAESR1 | |
| SCHEMBL9511722 | 0.78 | LTB4R (0.35) | LTB4RLTB4R2KDM4EALDH1A1GAA | |
| SCHEMBL9821719 | 0.77 | AKT1 (0.39) | AKT1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL10371731 | 0.77 | AKT1 (0.39) | AKT1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL9485831 | 0.77 | ALDH1A1 (0.36) | LTB4RLTB4R2KDM4EALDH1A1GAA | |
| SCHEMBL10818881 | 0.76 | ESR1 (0.34) | AKT1LTB4RLTB4R2ESR1ESR2 | |
| SCHEMBL10368416 | 0.76 | LTB4R (0.41) | AKT1LTB4RLTB4R2KDM4EALDH1A1 | |
| SCHEMBL10368286 | 0.75 | LTB4R (0.33) | LTB4RLTB4R2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0292977-B1 | ALKOXY-SUBSTITUTED DIHYDROBENZOPYRAN-2-CARBOXYLATE DERIVATIVES | G.D. Searle & Co. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-4889871-A | ANTIINFLAMMATORY AGENTS; SELECTIVE LEUKOTRIENE ANTAGONISTS | G. D. SEARLE & CO. (US) | 1989-12-26 | — | — | US | disclosed |
| EP-0292977-A1 | Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives | G.D. Searle & Co. (US) | 1988-11-30 | — | — | EP | disclosed |