Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9511722 | 0.87 | LTB4R (0.35) | LTB4RLTB4R2SLC22A12BACE1ESR1 | |
| SCHEMBL9821761 | 0.86 | AKT1 (0.38) | LTB4RLTB4R2SLC22A12BACE1ESR1 | |
| SCHEMBL10370656 | 0.81 | PPARG (0.52) | LTB4RLTB4R2 | |
| SCHEMBL10370648 | 0.81 | LTB4R (0.39) | LTB4RLTB4R2SLC22A12ESR1ESR2 | |
| SCHEMBL9485831 | 0.79 | ALDH1A1 (0.36) | LTB4RLTB4R2SLC22A12ESR1ESR2 | |
| SCHEMBL9511770 | 0.79 | ALDH1A1 (0.35) | LTB4RLTB4R2 | |
| SCHEMBL10371731 | 0.77 | AKT1 (0.39) | LTB4RLTB4R2SLC22A12 | |
| SCHEMBL9821730 | 0.75 | AKT1 (0.35) | LTB4RLTB4R2ESR1ESR2 | |
| SCHEMBL10368416 | 0.74 | LTB4R (0.41) | LTB4RLTB4R2SLC22A12ESR1ESR2 | |
| SCHEMBL10408545 | 0.73 | AKT1 (0.39) | LTB4RLTB4R2SLC22A12ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0254329-B1 | SUBSTITUTED DIHYDROBENZOPYRANONES | G.D. Searle & Co. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4952705-A | Substituted dihydrobenzopyrans | G. D. SEARLE & CO. (US) | 1990-08-28 | — | — | US | disclosed |
| US-4888356-A | Use of substituted dihydrobenzopyrans for allergy and inflammation | G. D. SEARLE AND COMPANY (US) | 1989-12-19 | — | — | US | disclosed |
| US-4778903-A | Substituted dihydrobenzopyrans | G. D. SEARLE & CO. (US) | 1988-10-18 | — | — | US | disclosed |
| EP-0254329-A1 | Substituted dihydrobenzopyranones | G.D. Searle & Co. (US) | 1988-01-27 | — | — | EP | disclosed |
| US-4665203-A | Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors | G. D. SEARLE & CO. (US) | 1987-05-12 | — | — | US | disclosed |
| EP-0139809-A1 | Substituted dihydrobenzopyrans | G.D. Searle & Co. (US) | 1985-05-08 | — | — | EP | disclosed |