Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 10/20 | 0.35 |
| ▸ | LTB4R2 | Q9NPC1 | 10/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | PTPRC | P08575 | 1/20 | 0.30 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9485831 | 0.91 | ALDH1A1 (0.36) | LTB4RLTB4R2SLC22A12ESR1ESR2 | |
| SCHEMBL9511770 | 0.91 | ALDH1A1 (0.35) | LTB4RLTB4R2KDM4EALDH1A1GLA | |
| SCHEMBL9821761 | 0.90 | AKT1 (0.38) | LTB4RLTB4R2SLC22A12BACE1ESR1 | |
| SCHEMBL10368286 | 0.87 | LTB4R (0.33) | LTB4RLTB4R2SLC22A12BACE1ESR1 | |
| SCHEMBL9511662 | 0.82 | ESR1 (0.33) | LTB4RLTB4R2SLC22A12ESR1ESR2 | |
| SCHEMBL9515500 | 0.81 | LTB4R (0.42) | LTB4RLTB4R2 | |
| SCHEMBL10371731 | 0.81 | AKT1 (0.39) | LTB4RLTB4R2SLC22A12KDM4EALDH1A1 | |
| SCHEMBL9511741 | 0.80 | ESR1 (0.32) | LTB4RLTB4R2SLC22A12ESR1ESR2 | |
| SCHEMBL9512237 | 0.80 | LTB4R (0.47) | LTB4RLTB4R2 | |
| SCHEMBL9821730 | 0.78 | AKT1 (0.35) | LTB4RLTB4R2ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0342664-B1 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | SEARLE & CO (US) | 1993-12-15 | — | — | EP | disclosed |
| US-5093353-A | 2,2-di-substituted benzopyran leukotriene-D4 antagonists | G. D. SEARLE & CO. (US) | 1992-03-03 | — | — | US | disclosed |
| EP-0342664-A2 | 2,2-disubstituted benzopyran leukotriene-D4 antagonists | G.D. Searle & Co. (US) | 1989-11-23 | — | — | EP | disclosed |