Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 11/20 | 0.49 |
| ▸ | RXRB | P28702 | 8/20 | 0.49 |
| ▸ | RXRG | P48443 | 6/20 | 0.49 |
| ▸ | RARB | P10826 | 7/20 | 0.42 |
| ▸ | RARG | P13631 | 7/20 | 0.42 |
| ▸ | RARA | P10276 | 6/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9822434 | 0.81 | RXRA (0.53) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9822386 | 0.76 | RXRA (0.68) | RXRARXRBRXRGRARBRARG | |
| Sumarotene SCHEMBL7062910 | 0.73 | RARG (0.70) | RXRARXRBRXRGRARBRARG | |
| Sumarotene SCHEMBL449752 | 0.73 | RARG (0.70) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9822438 | 0.72 | CYP26A1 (0.60) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9822432 | 0.72 | CYP26A1 (0.60) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7062909 | 0.71 | RARG (0.70) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9822470 | 0.70 | RXRA (0.52) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL9822584 | 0.69 | PTGS2 (0.39) | — | |
| Linarotene SCHEMBL636726 | 0.68 | HNF4A (0.51) | RXRARXRBRARBRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297995-B1 | POLYCYCLIC AROMATIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN HUMAN AND ANIMAL MEDICINE AND IN COSMETICS | L'OREAL (FR) | 1991-03-06 | — | — | EP | claimed |