Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833903 | 0.79 | MAPT (0.54) | KDM4ESMN1; SMN2MAPTNQO2ALDH1A1 | |
| SCHEMBL28345810 | 0.79 | NPSR1 (0.48) | KDM4ESMN1; SMN2MAPTNQO2TDP1 | |
| SCHEMBL2407562 | 0.76 | GLP1R (0.51) | KDM4ESMN1; SMN2MAPTALDH1A1HPGD | |
| SCHEMBL14734436 | 0.76 | ALDH1A1 (0.53) | KDM4ESMN1; SMN2MAPTNQO2TDP1 | |
| SCHEMBL11175138 | 0.75 | TDP1 (0.41) | KDM4EMAPTTDP1ALDH1A1GLA | |
| SCHEMBL2490986 | 0.74 | NQO2 (0.57) | KDM4ESMN1; SMN2MAPTNQO2TDP1 | |
| SCHEMBL3435829 | 0.72 | SMN1; SMN2 (0.48) | KDM4ESMN1; SMN2HSD17B10KMT2A | |
| SCHEMBL2179646 | 0.71 | ALDH1A1 (0.48) | KDM4ESMN1; SMN2MAPTNQO2TDP1 | |
| SCHEMBL31063992 | 0.70 | SMN1; SMN2 (0.46) | KDM4ESMN1; SMN2MAPTTDP1ALDH1A1 | |
| SCHEMBL2490947 | 0.69 | KDM4E (0.56) | KDM4ESMN1; SMN2MAPTNQO2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288898-B1 | SUBSTITUTED CHINOXALYL-IMIDAZOLIDINE-2,4-DIONES, PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND PHARMACOLOGICAL PREPARATIONS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-14 | — | — | EP | disclosed |
| US-4943576-A | ENZYME INHIBITORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-07-24 | — | — | US | disclosed |