Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.57 |
| ▸ | DHFR | P00374 | 6/20 | 0.55 |
| ▸ | IP6K1 | Q92551 | 5/20 | 0.46 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.46 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | FPGS | Q05932 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 6/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823121 | 0.87 | PDPK1 (0.46) | SLC2A1DHFRIP6K1IP6K3IP6K2 | |
| SCHEMBL9823450 | 0.82 | IP6K1 (0.47) | SLC2A1DHFRIP6K1IP6K3IP6K2 | |
| SCHEMBL9823281 | 0.82 | DHFR (0.56) | DHFRFPGS | |
| SCHEMBL10584902 | 0.81 | MMP13 (0.44) | IP6K1PDPK1 | |
| SCHEMBL9823195 | 0.72 | DHFR (0.45) | DHFRFPGS | |
| SCHEMBL9823134 | 0.71 | DHFR (1.00) | SLC2A1DHFR | |
| SCHEMBL9514916 | 0.70 | IP6K1 (0.52) | SLC2A1IP6K1IP6K3IP6K2PARP1 | |
| SCHEMBL9823278 | 0.70 | DHFR (0.47) | DHFRFPGS | |
| SCHEMBL9371240 | 0.69 | IP6K1 (0.61) | SLC2A1DHFRIP6K1IP6K3IP6K2 | |
| SCHEMBL9823104 | 0.68 | DHFR (0.44) | DHFRFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | claimed |
| US-4857530-A | THYMIDYLATE SYNTHASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-08-15 | — | — | US | claimed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | claimed |
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4857530-A | THYMIDYLATE SYNTHASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0316657-A1 | Substituted quinazolinones as anticancer agents | WARNER-LAMBERT COMPANY (US) | 1989-05-24 | — | — | EP | disclosed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | disclosed |