Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 11/20 | 0.56 |
| ▸ | FPGS | Q05932 | 2/20 | 0.43 |
| ▸ | TYMS | P04818 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ATIC | P31939 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823195 | 0.90 | DHFR (0.45) | DHFRFPGSTYMSATIC | |
| SCHEMBL9823278 | 0.87 | DHFR (0.47) | DHFRFPGSTYMS | |
| SCHEMBL9823104 | 0.87 | DHFR (0.44) | DHFRFPGSTYMSATIC | |
| SCHEMBL9823478 | 0.85 | DHFR (0.44) | DHFRFPGSTYMS | |
| SCHEMBL9823634 | 0.84 | DHFR (0.43) | DHFRFPGSTYMS | |
| SCHEMBL9823454 | 0.83 | DHFR (0.55) | DHFRTYMSATIC | |
| SCHEMBL9823392 | 0.83 | DHFR (0.40) | DHFRTYMS | |
| SCHEMBL9823481 | 0.83 | TYMS (0.43) | DHFRTYMSATIC | |
| SCHEMBL9823140 | 0.82 | SLC2A1 (0.57) | DHFRFPGS | |
| SCHEMBL10584902 | 0.75 | MMP13 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | claimed |
| US-4857530-A | THYMIDYLATE SYNTHASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-08-15 | — | — | US | claimed |
| EP-0316657-A1 | Substituted quinazolinones as anticancer agents | WARNER-LAMBERT COMPANY (US) | 1989-05-24 | — | — | EP | claimed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | claimed |
| EP-0426666-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4857530-A | THYMIDYLATE SYNTHASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1989-08-15 | — | — | US | disclosed |
| EP-0316657-A1 | Substituted quinazolinones as anticancer agents | WARNER-LAMBERT COMPANY (US) | 1989-05-24 | — | — | EP | disclosed |
| WO-1989004307-A1 | SUBSTITUTED QUINAZOLINONES AS ANTICANCER AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-05-18 | — | — | WO | disclosed |