Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.38 |
| ▸ | CASP1 | P29466 | 5/20 | 0.38 |
| ▸ | CASP7 | P55210 | 5/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824938 | 0.89 | ALDH1A1 (0.37) | CYP2C9LMNAATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824035 | 0.88 | KDM4E (0.39) | CYP2C9LMNAATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824074 | 0.85 | KMT2A (0.46) | ALDH1A1DPP4 | |
| SCHEMBL9825107 | 0.82 | LMNA (0.53) | CYP2C9LMNAATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824452 | 0.82 | DPP4 (0.41) | LMNAALDH1A1HSD17B10HPGDKDM4E | |
| SCHEMBL9824506 | 0.80 | ALDH1A1 (0.38) | CYP2C9LMNAALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL607119 | 0.80 | — | — | |
| SCHEMBL9824841 | 0.80 | LMNA (0.35) | CYP2C9LMNAATP6V1B2TBXA2REDNRA | |
| SCHEMBL9824623 | 0.80 | KDM4E (0.52) | CYP2C9LMNAALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL9824684 | 0.80 | TOP2A (0.36) | CYP2C9LMNAALDH1A1CYP1A2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227088-B1 | ISOXAZOLO-NAPHTHYRIDINE, ISOXAZOLO QUINOLINE, ISOTHIAZOLONAPHTHYRIDINE, AND ISOTHIAZOLOQUINOLINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1991-08-07 | — | — | EP | disclosed |
| US-4767762-A | Tricyclic quinoline and naphthyride antibacterials | ABBOTT LABORATORIES (US) | 1988-08-30 | — | — | US | disclosed |