Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10508128 | 0.85 | LTA4H (0.44) | OPRK1OPRD1LTA4HMEN1KMT2A | |
| SCHEMBL9824846 | 0.84 | CYP1A2 (0.42) | OPRD1MEN1KMT2ACHRM2CHRM4 | |
| SCHEMBL9824784 | 0.82 | OPRD1 (0.33) | OPRD1LTA4HMEN1KMT2A | |
| SCHEMBL9824780 | 0.82 | OPRD1 (0.33) | OPRD1LTA4HMEN1KMT2A | |
| SCHEMBL5014206 | 0.81 | KMT2A (0.48) | MEN1KMT2ATSHRLMNAALOX15 | |
| SCHEMBL9824064 | 0.81 | LTA4H (0.40) | OPRK1OPRD1LTA4HMEN1KMT2A | |
| SCHEMBL18878613 | 0.80 | ALDH1A1 (0.39) | OPRK1OPRD1LTA4HPOLBCHRM2 | |
| SCHEMBL6191432 | 0.80 | ALDH1A1 (0.46) | LTA4HMEN1KMT2APOLBPKM | |
| SCHEMBL18878629 | 0.76 | ALDH1A1 (0.42) | OPRK1OPRD1LTA4HTSHR | |
| SCHEMBL9824048 | 0.76 | S1PR1 (0.36) | OPRD1MEN1KMT2APOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |