Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 4/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825152 | 0.86 | BCHE (0.35) | SIGMAR1BCHECARM1PRMT6BACE1 | |
| SCHEMBL9825032 | 0.81 | HRH3 (0.41) | SIGMAR1BCHEALOX15BACE1 | |
| SCHEMBL11615967 | 0.79 | ALOX15 (0.41) | SIGMAR1BCHECARM1PRMT6ALOX15 | |
| SCHEMBL9824888 | 0.78 | HRH3 (0.41) | SIGMAR1ALOX15BACE1 | |
| SCHEMBL9824518 | 0.78 | SIGMAR1 (0.49) | SIGMAR1ALOX15 | |
| SCHEMBL9824415 | 0.76 | SIGMAR1 (0.44) | SIGMAR1CARM1PRMT6ALOX15 | |
| SCHEMBL9824505 | 0.74 | ALOX15 (0.41) | SIGMAR1CARM1PRMT6ALOX15 | |
| SCHEMBL9823964 | 0.72 | MEN1 (0.39) | BCHEBACE1 | |
| SCHEMBL10646171 | 0.71 | LSS (0.48) | BCHE | |
| SCHEMBL25653931 | 0.71 | BCHE (0.53) | BCHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |