Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 2/20 | 0.32 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.31 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9824839 | 0.86 | SIGMAR1 (0.50) | BCHESIGMAR1BACE1CARM1PRMT6 | |
| SCHEMBL9824411 | 0.82 | GNAO1 (0.43) | BCHESIGMAR1LSSGNAI3GNAO1 | |
| SCHEMBL9824779 | 0.81 | KMT2A (0.46) | BCHEMEN1KMT2ACARM1PRMT6 | |
| SCHEMBL20284250 | 0.80 | SIGMAR1 (0.38) | SIGMAR1LSSCHRM2CHRM4CHRM1 | |
| SCHEMBL9824437 | 0.80 | MAOB (0.34) | BCHEMEN1KMT2ASIGMAR1LSS | |
| SCHEMBL9825032 | 0.79 | HRH3 (0.41) | BCHESIGMAR1BACE1HRH3 | |
| SCHEMBL9824777 | 0.78 | GNAO1 (0.44) | GNAI3GNAO1GNAI1CHRM2CHRM4 | |
| SCHEMBL11615967 | 0.77 | ALOX15 (0.41) | BCHESIGMAR1CARM1PRMT6 | |
| SCHEMBL9824888 | 0.76 | HRH3 (0.41) | SIGMAR1BACE1HRH3 | |
| SCHEMBL9823964 | 0.75 | MEN1 (0.39) | BCHEMEN1KMT2ABACE1GNAI3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |