Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 3/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9823863 | 0.92 | GNAI3 (0.42) | MEN1KMT2ABCHEGNAI3GNAO1 | |
| SCHEMBL9824779 | 0.88 | KMT2A (0.46) | MEN1KMT2ABCHEL3MBTL1 | |
| SCHEMBL9824121 | 0.81 | GNAI3 (0.40) | MEN1KMT2AGNAI3GNAO1GNAI1 | |
| SCHEMBL9824395 | 0.79 | MEN1 (0.34) | MEN1KMT2ABCHEDRD2DRD3 | |
| SCHEMBL9825152 | 0.75 | BCHE (0.35) | MEN1KMT2ABCHEGNAI3GNAO1 | |
| SCHEMBL11615967 | 0.73 | ALOX15 (0.41) | BCHE | |
| SCHEMBL18542759 | 0.72 | DRD2 (0.45) | BCHEDRD2DRD1DRD4DRD5 | |
| SCHEMBL10064309 | 0.72 | CYP2D6 (0.45) | BCHEGNAI3GNAO1GNAI1 | |
| SCHEMBL14756462 | 0.72 | GNAO1 (0.46) | GNAI3GNAO1GNAI1DRD2DRD4 | |
| SCHEMBL3897612 | 0.72 | CYP2D6 (0.45) | BCHEGNAI3GNAO1GNAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |