Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTR4 | Q13639 | 12/20 | 0.35 |
| ▸ | ACHE | P22303 | 11/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825410 | 0.82 | LMNA (0.38) | KDM4EHTR4ACHEPOLBPKM | |
| SCHEMBL9824850 | 0.80 | SIGMAR1 (0.42) | KDM4EHTR4ACHETSHRALDH1A1 | |
| SCHEMBL9824435 | 0.78 | ALDH1A1 (0.39) | KDM4EACHEPOLBPKMTSHR | |
| SCHEMBL5337084 | 0.73 | CHRM1 (0.48) | KDM4EHTR4ACHEPOLBPKM | |
| SCHEMBL9824227 | 0.73 | ALDH1A1 (0.41) | KDM4EACHEPOLBPKMTSHR | |
| SCHEMBL9824622 | 0.73 | CHRM2 (0.40) | KDM4EACHEPOLBPKMTSHR | |
| SCHEMBL11981499 | 0.72 | KDM4E (0.48) | KDM4EPOLBPKMTSHRALDH1A1 | |
| SCHEMBL9824197 | 0.71 | GNAI3 (0.39) | HTR4 | |
| SCHEMBL22006816 | 0.71 | HTT (0.47) | KDM4EHTR4ACHEPOLBPKM | |
| SCHEMBL2603216 | 0.71 | KDM4E (0.47) | KDM4EPOLBPKMTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0273239-B1 | CONDENSED DIAZEPINONES, PROCESSES FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1991-03-06 | — | — | EP | disclosed |
| US-4873236-A | BRADYCARDIAL AGENTS | DR. KARL THOMAE GMBH (DE) | 1989-10-10 | — | — | US | disclosed |
| EP-0273239-A1 | Condensed diazepinones, processes for their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1988-07-06 | — | — | EP | disclosed |