SCHEMBL9824975

SCHEMBL9824975

CCCOC(=O)CSc1cc(/N=c2/sc(=O)n3n2CCCC3)c(F)cc1Cl

nearest known ligand 0.80

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPOX P50336 4/20 0.36
ALDH1A1 P00352 3/20 0.32
HPGD P15428 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
HSD17B10 Q99714 1/20 0.32
GAA P10253 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
LMNA P02545 1/20 0.31
RECQL P46063 1/20 0.31
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9824983 1.00 PPOX (0.36) PPOXALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL8562796 0.95 ALDH1A1 (0.34) PPOXALDH1A1CYP1A2CYP3A4CYP2C9
SCHEMBL9824707 0.94 TP53 (0.33) PPOXALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL9824710 0.94 TP53 (0.33) PPOXALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL9824569 0.93 GAA (0.37) PPOXALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL9824563 0.93 GAA (0.37) PPOXALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL9551231 0.91 ALDH1A1 (0.36) PPOXALDH1A1HPGDCYP1A2CYP3A4
Fluthiacetmethyl SCHEMBL8437784 0.89 KMT2A (0.35) PPOXALDH1A1HPGDTSHRHSD17B10
Fluthiacetmethyl SCHEMBL39080 0.89 KMT2A (0.35) PPOXALDH1A1HPGDTSHRHSD17B10
Fluthiacetmethyl SCHEMBL29405302 0.89 KMT2A (0.35) PPOXALDH1A1HPGDTSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0273417-B1 THIADIAZABICYCLONONANE DERIVATIVES AND HERBICIDAL COMPOSITIONS KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) 1991-08-21 EP disclosed
US-4906279-A Thiadiazabicyclononane derivatives and herbicidal composition KUMIAI CHEMICAL INDUSTRY CO. (JP) 1990-03-06 US disclosed