Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825726 | 0.95 | MTNR1A (0.45) | HTTMTNR1ADRD2HTR1A | |
| SCHEMBL9826865 | 0.95 | MTNR1A (0.45) | HTTMTNR1ADRD2HTR1A | |
| Hydrochloric Acid SCHEMBL9825354 | 0.94 | MTNR1A (0.44) | HTTMTNR1ADRD2HTR1A | |
| Fumaric Acid SCHEMBL9691873 | 0.86 | HTT (0.46) | HTTHTR1A | |
| Fumaric Acid SCHEMBL9691879 | 0.86 | HTT (0.46) | HTTHTR1A | |
| SCHEMBL9825765 | 0.85 | MTNR1A (0.45) | HTTMTNR1ADRD2HTR1A | |
| SCHEMBL9825953 | 0.82 | POLB (0.43) | HTTMTNR1AHTR1A | |
| SCHEMBL9825617 | 0.82 | POLB (0.43) | HTTMTNR1AHTR1A | |
| SCHEMBL9692918 | 0.80 | HTT (0.48) | HTTMTNR1ADRD2HTR1A | |
| SCHEMBL9692391 | 0.80 | HTT (0.48) | HTTMTNR1ADRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252005-B1 | HYDROGENATED 1-BENZOOXACYCLOALKYL-PYRIDINE CARBOXYLIC-ACID COMPOUNDS | CIBA-GEIGY AG (CH) | 1991-07-10 | — | — | EP | disclosed |
| EP-0252005-A1 | Hydrogenated 1-benzooxacycloalkyl-pyridine carboxylic-acid compounds | CIBA-GEIGY AG (CH) | 1988-01-07 | — | — | EP | disclosed |