Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.57 |
| ▸ | DRD3 | P35462 | 4/20 | 0.57 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | DRD1 | P21728 | 2/20 | 0.55 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825650 | 0.88 | DRD3 (0.57) | HRH3DRD3DRD2HTR2AHTR1A | |
| SCHEMBL9825581 | 0.87 | HRH3 (0.76) | HRH3DRD3DRD2HTR2AHTR1A | |
| Hydrochloric Acid SCHEMBL9825840 | 0.87 | DRD3 (0.56) | HRH3DRD3DRD2HTR2AHTR1A | |
| SCHEMBL9826692 | 0.77 | DRD2 (0.55) | HRH3DRD3DRD2HTR2AHTR1A | |
| SCHEMBL9825781 | 0.77 | HRH3 (0.66) | HRH3DRD3DRD2HTR2AHTR1A | |
| SCHEMBL9825874 | 0.76 | HTR2A (0.54) | HRH3DRD3DRD2HTR2AHTR1A | |
| SCHEMBL9826050 | 0.75 | KCNA3 (0.55) | HRH3DRD3DRD2HTR1AKCNA3 | |
| Hydrochloric Acid SCHEMBL9826723 | 0.74 | KCNA3 (0.54) | HRH3DRD3DRD2HTR1AKCNA3 | |
| SCHEMBL1545737 | 0.74 | KCNA3 (0.71) | KCNA3MEN1KMT2ATDP1 | |
| SCHEMBL8810727 | 0.73 | HTR2A (0.52) | HRH3DRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237781-B1 | PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4803203-A | SCHIZOPHRENIA, NEUOLEPTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-02-07 | — | — | US | disclosed |
| US-4704390-A | SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0237781-A2 | Phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | disclosed |