Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 5/20 | 0.49 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9826723 | 0.99 | KCNA3 (0.54) | KCNA3SIGMAR1PARP1DRD3DRD2 | |
| SCHEMBL9825804 | 0.79 | SIGMAR1 (0.53) | SIGMAR1PARP1DRD3DRD2DRD4 | |
| SCHEMBL9825581 | 0.78 | HRH3 (0.76) | KCNA3SIGMAR1DRD3DRD2HRH3 | |
| SCHEMBL9825701 | 0.77 | HTR1A (0.70) | DRD3DRD2DRD4HTR1ASLC6A4 | |
| SCHEMBL9825914 | 0.75 | HRH3 (0.57) | KCNA3DRD3DRD2HRH3HTR1A | |
| SCHEMBL9825650 | 0.74 | DRD3 (0.57) | KCNA3DRD3DRD2HRH3HTR1A | |
| Hydrochloric Acid SCHEMBL9825840 | 0.74 | DRD3 (0.56) | KCNA3DRD3DRD2HRH3HTR1A | |
| SCHEMBL9825205 | 0.74 | HTR1A (0.68) | DRD3DRD2DRD4HTR1ASLC6A4 | |
| SCHEMBL9473840 | 0.71 | SIGMAR1 (0.92) | SIGMAR1PARP1DRD3DRD2DRD4 | |
| SCHEMBL9467947 | 0.71 | SIGMAR1 (0.66) | SIGMAR1PARP1DRD3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0237781-B1 | PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | claimed |
| US-4704390-A | SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 1987-11-03 | — | — | US | claimed |
| EP-0237781-A2 | Phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | claimed |
| EP-0237781-B1 | PHENYL AND HETEROCYCLIC TETRAHYDROPYRIDYL AND PIPERAZINYL ALKOXY-BENZHETEROCYCLIC COMPOUNDS AS ANTIPSYCHOTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4803203-A | SCHIZOPHRENIA, NEUOLEPTIC AGENTS | WARNER-LAMBERT COMPANY (US) | 1989-02-07 | — | — | US | disclosed |
| US-4704390-A | SCHIZOPHRENIA | WARNER-LAMBERT COMPANY (US) | 1987-11-03 | — | — | US | disclosed |
| EP-0237781-A2 | Phenyl and heterocyclic tetrahydropyridyl and piperazinyl alkoxy-benzheterocyclic compounds as antipsychotic agents | WARNER-LAMBERT COMPANY (US) | 1987-09-23 | — | — | EP | disclosed |