Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826288 | 0.85 | ALDH1A1 (0.46) | ATMKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL7848089 | 0.76 | ALDH1A1 (0.72) | RAB9AKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL834652 | 0.74 | RAB9A (0.50) | ESR2RAB9AKMT2AMEN1L3MBTL1 | |
| SCHEMBL28047062 | 0.74 | ALDH1A1 (0.44) | ATMESR2RAB9AKMT2AMEN1 | |
| SCHEMBL1162160 | 0.72 | RAB9A (0.48) | ESR2RAB9AKMT2AALDH1A1L3MBTL1 | |
| SCHEMBL11587492 | 0.71 | KDM4E (0.56) | RAB9AKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL11659943 | 0.70 | RAB9A (0.54) | ESR2RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL1840806 | 0.70 | KMT2A (0.70) | ESR2RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL20505372 | 0.70 | RAB9A (0.47) | ESR2RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL8542954 | 0.70 | CA12 (0.55) | ALDH1A1L3MBTL1P2RX3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249236-B1 | N-1H-TETRAZOL-5-YL-(5-RING)-CARBOXAMIDE-DERIVATIVES, A PROCESS FOR THEIR MANUFACTURE, AND THE USE THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4824958-A | Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides | WARNER-LAMBERT COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| US-4748183-A | N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0249236-A1 | N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof | WARNER-LAMBERT COMPANY (US) | 1987-12-16 | — | — | EP | disclosed |