Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRM6 | O15303 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827009 | 0.86 | TRPM8 (0.51) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL9031450 | 0.79 | ALDH1A1 (0.56) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL11101577 | 0.77 | TSHR (0.53) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2060498 | 0.76 | GRM6 (0.65) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL27592419 | 0.76 | ALDH1A1 (0.54) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL6872798 | 0.76 | TRPM8 (0.51) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL1086028 | 0.75 | KMT2A (0.56) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL68469 | 0.75 | PLA2G1B (0.60) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL2063549 | 0.75 | ALDH1A1 (0.52) | TRPM8ALDH1A1HPGDKDM4EHSD17B10 | |
| SCHEMBL10431407 | 0.74 | TRPM8 (0.52) | TRPM8ALDH1A1HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0249236-B1 | N-1H-TETRAZOL-5-YL-(5-RING)-CARBOXAMIDE-DERIVATIVES, A PROCESS FOR THEIR MANUFACTURE, AND THE USE THEREOF | WARNER-LAMBERT COMPANY (US) | 1991-04-24 | — | — | EP | disclosed |
| US-4824958-A | Process for the preparation of n-1H-tetrazol-5-yl-2-pyrrole carboxamides | WARNER-LAMBERT COMPANY (US) | 1989-04-25 | — | — | US | disclosed |
| US-4748183-A | N-1H-tetrazol-5-yl-2-thiophene carboxamides, N-1H-tetrazol-5-yl-2-pyrrole carboxamides, N-1H-tetrazol-5-yl-2-furan carboxamides, and anti-allergic and anti-inflammatory use thereof | WARNER-LAMBERT COMPANY (US) | 1988-05-31 | — | — | US | disclosed |
| EP-0249236-A1 | N-1H-Tetrazol-5-yl-(5-Ring)-carboxamide-derivatives, a process for their manufacture, and the use thereof | WARNER-LAMBERT COMPANY (US) | 1987-12-16 | — | — | EP | disclosed |