Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9825661 | 0.92 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9825332 | 0.92 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9826859 | 0.91 | ALDH1A1 (0.41) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9825897 | 0.91 | KMT2A (0.35) | MEN1KMT2ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL9826486 | 0.91 | PIK3CA (0.38) | MEN1KMT2ASMN1; SMN2ALDH1A1FKBP1A | |
| SCHEMBL9825542 | 0.89 | SMN1; SMN2 (0.37) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9825754 | 0.89 | ACACB (0.40) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9825679 | 0.88 | ALDH1A1 (0.36) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL9826243 | 0.86 | ALDH1A1 (0.37) | MEN1KMT2AALDH1A1LMNAMAPK1 | |
| SCHEMBL9825810 | 0.85 | SMN1; SMN2 (0.39) | MEN1KMT2ASMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239815-B1 | SUBSTITUTED THIAZOLES AND OXAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1991-07-24 | — | — | EP | disclosed |
| EP-0239815-A1 | Substituted thiazoles and oxazoles, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-10-07 | — | — | EP | disclosed |