Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9826846 | 0.92 | SMN1; SMN2 (0.34) | SMN1; SMN2ALDH1A1HPGDACACB | |
| SCHEMBL9825575 | 0.92 | ALDH1A1 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1FKBP1A | |
| SCHEMBL9825803 | 0.91 | MCHR1 (0.34) | SMN1; SMN2MEN1KMT2AALDH1A1FKBP1A | |
| SCHEMBL9825436 | 0.91 | PIK3CA (0.35) | SMN1; SMN2MEN1KMT2AALDH1A1FKBP1A | |
| SCHEMBL9825661 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9825332 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9826314 | 0.89 | MEN1 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9826520 | 0.87 | CNR2 (0.34) | MEN1KMT2AMOGAT2 | |
| SCHEMBL9825694 | 0.87 | GAA (0.34) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9827149 | 0.87 | ALDH1A1 (0.37) | MEN1KMT2AALDH1A1MOGAT2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239815-B1 | SUBSTITUTED THIAZOLES AND OXAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1991-07-24 | — | — | EP | disclosed |
| EP-0239815-A1 | Substituted thiazoles and oxazoles, medicines containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-10-07 | — | — | EP | disclosed |