Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10934516 | 1.00 | GAA (0.54) | GAAL3MBTL1POLBPLA2G4BKDM4E | |
| SCHEMBL9826297 | 0.93 | POLB (0.54) | GAAL3MBTL1POLBPLA2G4BKDM4E | |
| SCHEMBL7153441 | 0.88 | POLB (0.56) | GAAL3MBTL1POLBPLA2G4BKDM4E | |
| SCHEMBL9630085 | 0.85 | GAA (0.57) | GAAL3MBTL1POLBPLA2G4BKDM4E | |
| Ethylene SCHEMBL10898008 | 0.85 | POLB (0.53) | GAAL3MBTL1POLBPLA2G4BKDM4E | |
| SCHEMBL8347541 | 0.84 | KDM4E (0.68) | POLBPLA2G4BKDM4ECYP1A2CYP2D6 | |
| SCHEMBL1376135 | 0.83 | POLB (0.54) | GAAL3MBTL1POLBPLA2G4BKDM4E | |
| SCHEMBL2628204 | 0.83 | ALDH1A1 (0.58) | GAAL3MBTL1POLBKDM4ECYP1A2 | |
| SCHEMBL2628192 | 0.83 | ALDH1A1 (0.58) | GAAL3MBTL1POLBKDM4ECYP1A2 | |
| SCHEMBL11150154 | 0.83 | L3MBTL1 (0.59) | GAAL3MBTL1POLBPLA2G4BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0239815-B1 | SUBSTITUTED THIAZOLES AND OXAZOLES, MEDICINES CONTAINING THESE COMPOUNDS AND PROCESS FOR THEIR PREPARATION | Dr. Karl Thomae GmbH (DE) | 1991-07-24 | — | — | EP | disclosed |
| EP-0052963-B1 | SECONDARY AMINES | BEECHAM GROUP PLC (GB) | 1985-02-20 | — | — | EP | disclosed |
| US-4382958-A | Secondary amines and compositions for treatment of hypoglycaemia or obesity | BEECHAM GROUP LIMITED (GB) | 1983-05-10 | — | — | US | disclosed |
| EP-0052963-A1 | Secondary amines | BEECHAM GROUP PLC (GB) | 1982-06-02 | — | — | EP | disclosed |