Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | PRKCI | P41743 | 1/20 | 0.35 |
| ▸ | P4HB | P07237 | 1/20 | 0.32 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9521121 | 0.89 | MAOB (0.40) | MAOAMAOBPRKCIMAPTNPC1 | |
| SCHEMBL9521410 | 0.82 | ACHE (0.53) | PSMB5MAOAMAOBACHEEGFR | |
| SCHEMBL3964318 | 0.79 | MAOB (0.42) | MAOAMAOBNPC1HTTRAB9A | |
| SCHEMBL6112997 | 0.79 | ACHE (0.53) | PSMB5MAOAMAOBACHEEGFR | |
| SCHEMBL6112844 | 0.79 | ACHE (0.53) | PSMB5MAOAMAOBACHEEGFR | |
| SCHEMBL23966083 | 0.76 | MAOB (0.40) | MAOAMAOBACHENPC1RAB9A | |
| SCHEMBL2886044 | 0.76 | MAPT (0.42) | MAOAMAOBPRKCIMAPTNPC1 | |
| SCHEMBL22183626 | 0.76 | MAOB (0.40) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1535917 | 0.72 | ACHE (0.56) | PSMB5MAOAMAOBACHEEGFR | |
| SCHEMBL17362278 | 0.70 | MAOA (0.39) | MAOAMAOBPRKCIHSD17B1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395734-A4 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | — | 1991-01-02 | — | — | EP | disclosed |
| EP-0395734-A1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | ABBOTT LABORATORIES (US) | 1990-11-07 | — | — | EP | disclosed |
| WO-1989006645-A1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | ABBOTT LABORATORIES (US) | 1989-07-27 | — | — | WO | disclosed |