Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22940435 | 0.73 | AURKA (0.59) | AURKAAURKBGSK3BRAB9ANPC1 | |
| SCHEMBL9827717 | 0.71 | TUBB4A (0.55) | GSK3BRAB9ANPC1TDP1MAPT | |
| SCHEMBL20008234 | 0.70 | CYP1A2 (0.49) | RAB9ANPC1TDP1MAPTKDM4E | |
| SCHEMBL23641151 | 0.70 | GSK3B (0.62) | AURKAAURKBGSK3BRAB9ANPC1 | |
| SCHEMBL9828516 | 0.70 | AURKA (0.55) | AURKAAURKBGSK3BRAB9ANPC1 | |
| SCHEMBL21672916 | 0.69 | EHMT2 (0.53) | RAB9ANPC1TDP1MAPTKDM4E | |
| SCHEMBL374022 | 0.69 | RAB9A (0.74) | AURKAAURKBGSK3BRAB9ANPC1 | |
| SCHEMBL29631691 | 0.69 | RAB9A (0.74) | AURKAAURKBGSK3BRAB9ANPC1 | |
| SCHEMBL13831039 | 0.69 | AURKA (0.50) | AURKAAURKBGSK3BRAB9ANPC1 | |
| SCHEMBL24326363 | 0.68 | TDP1 (0.46) | RAB9ANPC1TDP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422178-A1 | PYRIMIDINE DERIVATIVES. | ICI PLC (GB) | 1991-04-17 | — | — | EP | disclosed |