Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | TSPO | P30536 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9827424 | 0.89 | CHEK1 (0.45) | CHEK1RAB9ACES1TSPOCHRM2 | |
| SCHEMBL9827381 | 0.83 | CHEK1 (0.50) | CHEK1RAB9ACES1TSPOCHRM2 | |
| SCHEMBL9827434 | 0.80 | RAB9A (0.59) | CHEK1RAB9ACHRM2CHRM4CHRM1 | |
| SCHEMBL9827608 | 0.78 | RAB9A (0.48) | CHEK1RAB9ACHRM2CHRM4CHRM1 | |
| SCHEMBL9594444 | 0.76 | DRD2 (0.45) | CHEK1RAB9ACHRM2CHRM4CHRM1 | |
| SCHEMBL8249206 | 0.76 | CHEK1 (0.54) | CHEK1CES1CHRM2TGM2 | |
| SCHEMBL9595138 | 0.76 | DRD2 (0.46) | CHEK1RAB9ACHRM2CHRM4CHRM1 | |
| SCHEMBL9595120 | 0.76 | DRD2 (0.46) | CHEK1RAB9ACHRM2CHRM4CHRM1 | |
| SCHEMBL9595405 | 0.75 | CHRM2 (0.47) | RAB9ACHRM2CHRM1 | |
| SCHEMBL9827820 | 0.75 | TSHR (0.46) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139627-B1 | Process for the preparation of 5,10-dihydro-1H-dibenzo [B,E] [1,4] diazepin-11-ones substituted in position 5 | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1991-05-22 | — | — | EP | disclosed |
| EP-0139627-A1 | Process for the preparation of 5,10-dihydro-1H-dibenzo [B,E] [1,4] diazepin-11-ones substituted in position 5 | ARZNEIMITTELWERK DRESDEN GmbH (DE) | 1985-05-02 | — | — | EP | disclosed |