Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP1 | P09455 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.37 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.37 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10796276 | 0.79 | RBP1 (0.41) | RBP1ALDH1A1GAAHPGDKDM4E | |
| SCHEMBL11420697 | 0.77 | ALDH1A1 (0.38) | RBP1CYP1A2SRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL11219994 | 0.77 | ALDH1A1 (0.38) | RBP1CYP1A2SRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL11433125 | 0.77 | RBP1 (0.40) | RBP1ALDH1A1GAAHPGDKDM4E | |
| SCHEMBL9828660 | 0.77 | HSD17B10 (0.39) | ALDH1A1KDM4EHSD17B10TSHR | |
| SCHEMBL11123284 | 0.74 | ALDH1A1 (0.38) | RBP1CYP1A2ALDH1A1GAAHPGD | |
| SCHEMBL11123894 | 0.74 | ALDH1A1 (0.38) | RBP1CYP1A2ALDH1A1GAAHPGD | |
| SCHEMBL11010508 | 0.73 | ADRA1A (0.38) | RBP1CYP1A2SRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL28449241 | 0.73 | ADRA1A (0.38) | RBP1CYP1A2SRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL6817658 | 0.73 | ALDH1A1 (0.42) | HTTCYP1A2ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177960-B1 | DERIVATIVES OF TETRAHYDRONAPHTHALENE, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOFFMANN LA ROCHE (CH) | 1991-03-20 | — | — | EP | disclosed |
| US-4680310-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0177960-A2 | Derivatives of tetrahydronaphthalene, process and intermediates for their preparation and medicines containing them | F. HOFFMANN-LA ROCHE AG (CH) | 1986-04-16 | — | — | EP | disclosed |