Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 9/20 | 0.67 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.58 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.58 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | IL2 | P60568 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829301 | 1.00 | GPR132 (0.67) | GPR132GPR139PTPN1CMKLR2CMKLR1 | |
| SCHEMBL4173706 | 0.91 | GPR132 (0.76) | GPR132GPR139PTPN1CMKLR2CMKLR1 | |
| SCHEMBL18114395 | 0.88 | GPR132 (0.81) | GPR132GPR139PTPN1CMKLR2CMKLR1 | |
| SCHEMBL18127321 | 0.85 | GPR132 (0.61) | GPR132GPR139PTPN1CMKLR2CMKLR1 | |
| SCHEMBL8667629 | 0.85 | CA2 (0.72) | GPR132PTPN1LNPEPCTSLCA2 | |
| SCHEMBL8671908 | 0.85 | CA2 (0.72) | GPR132PTPN1LNPEPCTSLCA2 | |
| SCHEMBL5926365 | 0.83 | PTPN1 (0.62) | GPR132GPR139PTPN1CTSLCA2 | |
| SCHEMBL31389144 | 0.83 | GPR139 (0.72) | GPR132GPR139CMKLR2CMKLR1CTSL | |
| SCHEMBL4178541 | 0.83 | GPR139 (0.72) | GPR132GPR139CMKLR2CMKLR1CTSL | |
| SCHEMBL5926200 | 0.82 | PTPN1 (0.64) | GPR132GPR139PTPN1CTSLCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0226304-B1 | COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC | SANKYO COMPANY LIMITED (JP) | 1991-08-28 | — | — | EP | disclosed |
| US-4757066-A | Reduces renal toxicity | SANKYO COMPANY LIMITED (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0226304-A1 | Composition containing a penem or carbapenem antibiotic | SANKYO COMPANY LIMITED (JP) | 1987-06-24 | — | — | EP | disclosed |