Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29688897 | 0.79 | DDB1 (0.43) | DRD2SLC6A4CYP1A2GRM4SSTR4 | |
| SCHEMBL8127288 | 0.79 | DDB1 (0.43) | DRD2SLC6A4CYP1A2GRM4SSTR4 | |
| SCHEMBL10395935 | 0.79 | CDK9 (0.42) | DRD2SSTR4HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL10395915 | 0.78 | DDB1 (0.43) | DRD2SLC6A4CYP1A2GRM4SSTR4 | |
| SCHEMBL9092322 | 0.77 | DRD2 (0.47) | DRD2SLC6A4ACHEHTR2AHTR7 | |
| SCHEMBL9092812 | 0.77 | DRD2 (0.45) | DRD2SLC6A4ACHEHTR2AHTR7 | |
| SCHEMBL9829589 | 0.76 | SSTR4 (0.39) | DRD2SLC6A4ACHECYP1A2GRM4 | |
| SCHEMBL10396273 | 0.74 | CNR1 (0.42) | USP30 | |
| SCHEMBL9830318 | 0.73 | RBP4 (0.41) | DRD2SLC6A4ACHEUSP30HTR2A | |
| SCHEMBL15345100 | 0.73 | CYP1A2 (0.41) | CYP1A2GRM4DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0192935-B1 | 3-(PIPERIDINYL)-1H-INDAZOLES A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-02-27 | — | — | EP | disclosed |
| US-4933460-A | CHEMICAL INTERMEDIATES FOR INDAZOLE-CONTAINING DRUGS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-06-12 | — | — | US | disclosed |
| US-4853470-A | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-08-01 | — | — | US | disclosed |
| US-4806649-A | ANTIDEPRESSANTS, ANTICONVULSANTS, ANALGESICS, HYPOTENSIVE AGENTS, ANTIHALLUCINOGENS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4775761-A | TREATING PSYCHOSES, DEPRESSION, CONVULSIONS AND HYPERTENSION | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-10-04 | — | — | US | disclosed |
| US-4758668-A | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-07-19 | — | — | US | disclosed |
| US-4710573-A | PSYCHOLOGICAL DISORDERS | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-12-01 | — | — | US | disclosed |
| US-4670447-A | ANALGESICS, ANTIDEPRESSANTS, ANTICONVULSANTS AND HYPOTENSIVE AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1987-06-02 | — | — | US | disclosed |
| EP-0192935-A1 | 3-(piperidinyl)-1H-indazoles a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-09-03 | — | — | EP | disclosed |