Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829521 | 0.93 | ALDH1A1 (0.50) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL9829166 | 0.86 | ALDH1A1 (0.56) | KMT2AALDH1A1MEN1KDM4ECYP3A4 | |
| SCHEMBL9830061 | 0.84 | SMN1; SMN2 (0.44) | KMT2AALDH1A1MEN1KDM4ECYP3A4 | |
| SCHEMBL9829941 | 0.81 | ALDH1A1 (0.42) | KMT2AALDH1A1MEN1KDM4ECYP3A4 | |
| SCHEMBL10407429 | 0.79 | ALDH1A1 (0.52) | KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL9833066 | 0.79 | ALDH1A1 (0.48) | KMT2AALDH1A1GAA | |
| SCHEMBL9830898 | 0.79 | ALDH1A1 (0.55) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL491077 | 0.78 | ALDH1A1 (0.62) | KMT2AALDH1A1MEN1KDM4EGAA | |
| SCHEMBL9830213 | 0.78 | BCHE (0.49) | KMT2AALDH1A1MEN1KDM4E | |
| SCHEMBL9832835 | 0.78 | ALDH1A1 (0.47) | KMT2AALDH1A1MEN1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |