Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA9 | Q16790 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831033 | 0.92 | ALDH1A1 (0.40) | ALDH1A1CYP3A4KDM4EMEN1KMT2A | |
| SCHEMBL9832835 | 0.86 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9832189 | 0.85 | ALDH1A1 (0.49) | ALDH1A1KDM4EMEN1KMT2AHTT | |
| SCHEMBL9829166 | 0.85 | ALDH1A1 (0.56) | ALDH1A1CYP3A4KDM4EMEN1KMT2A | |
| SCHEMBL9831610 | 0.83 | ACHE (0.53) | BCHEACHE | |
| SCHEMBL9830195 | 0.81 | KMT2A (0.52) | ALDH1A1CYP3A4KDM4EMEN1KMT2A | |
| SCHEMBL9829851 | 0.79 | HSD17B10 (0.51) | ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL9832327 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KDM4EMEN1KMT2AHTT | |
| SCHEMBL10407429 | 0.78 | ALDH1A1 (0.52) | ALDH1A1KDM4EMEN1KMT2ACA1 | |
| SCHEMBL9830061 | 0.77 | SMN1; SMN2 (0.44) | ALDH1A1CYP3A4KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |