Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TSPO | P30536 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829851 | 0.93 | HSD17B10 (0.51) | ALDH1A1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL9832189 | 0.92 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL9829941 | 0.86 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9831610 | 0.85 | ACHE (0.53) | — | |
| SCHEMBL9832327 | 0.85 | ALDH1A1 (0.50) | ALDH1A1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL9833066 | 0.82 | ALDH1A1 (0.48) | ALDH1A1KMT2ALMNATSHRTSPO | |
| SCHEMBL9833033 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AHSD17B10KDM4E | |
| SCHEMBL9829166 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AKDM4ELMNA | |
| SCHEMBL28192703 | 0.81 | LPAR1 (0.47) | ALDH1A1HSD17B10 | |
| SCHEMBL9830213 | 0.81 | BCHE (0.49) | ALDH1A1MEN1KMT2AKDM4ETSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |