Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | RARA | P10276 | 2/20 | 0.43 |
| ▸ | RARB | P10826 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9830967 | 0.88 | SRD5A1 (0.49) | SRD5A1SRD5A2PRMT1ALDH1A1RARA | |
| SCHEMBL9832862 | 0.86 | ALDH1A1 (0.52) | SRD5A1SRD5A2PRMT1ALDH1A1RARA | |
| SCHEMBL9832356 | 0.85 | L3MBTL1 (0.54) | SRD5A1SRD5A2ALDH1A1KDM4EMAPK1 | |
| SCHEMBL9831632 | 0.84 | HSD17B2 (0.53) | SRD5A1SRD5A2PRMT1ALDH1A1RARA | |
| SCHEMBL9831758 | 0.81 | KDM4E (0.42) | ALDH1A1KDM4EPOLBMAPTHSP90AA1 | |
| SCHEMBL31593035 | 0.81 | WDR5 (0.53) | SRD5A1SRD5A2PRMT1ALDH1A1RARA | |
| SCHEMBL28961520 | 0.80 | PRMT1 (0.47) | SRD5A1SRD5A2PRMT1ALDH1A1RARA | |
| SCHEMBL9829081 | 0.79 | ALDH1A1 (0.55) | ALDH1A1CA12CA1CA2CA7 | |
| SCHEMBL9832079 | 0.79 | PDE3B (0.40) | SRD5A1SRD5A2ALDH1A1CA12CA1 | |
| SCHEMBL9832735 | 0.76 | ALDH1A1 (0.45) | SRD5A1SRD5A2ALDH1A1RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | claimed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | claimed |