Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829593 | 0.80 | KCNK3 (0.40) | LMNAMAPTKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL9829266 | 0.79 | CA9 (0.60) | LMNAMAPTKMT2AMEN1KDM4E | |
| SCHEMBL9831086 | 0.79 | POLB (0.44) | LMNAMAPTKMT2AMEN1KDM4E | |
| SCHEMBL9829914 | 0.78 | HSD17B2 (0.51) | LMNAMAPTKMT2AMEN1KDM4E | |
| SCHEMBL9831170 | 0.77 | KMT2A (0.59) | LMNAMAPTKMT2AMEN1ADORA1 | |
| SCHEMBL9829764 | 0.76 | MEN1 (0.45) | LMNAMAPTKMT2AMEN1ADORA1 | |
| SCHEMBL9829278 | 0.75 | KMT2A (0.58) | MAPTKMT2AMEN1KDM4EGAA | |
| SCHEMBL9830068 | 0.73 | KMT2A (0.49) | LMNAMAPTKMT2AMEN1KDM4E | |
| SCHEMBL9829790 | 0.72 | ALDH1A1 (0.41) | LMNAMAPTKMT2AMEN1ADORA1 | |
| SCHEMBL9829064 | 0.71 | ALDH1A1 (0.43) | LMNAMAPTKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |