Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829064 | 0.87 | ALDH1A1 (0.43) | HSD17B2ALDH1A1POLBTDP1TSHR | |
| SCHEMBL9831086 | 0.83 | POLB (0.44) | ALDH1A1POLBTDP1TSHRMAPK1 | |
| SCHEMBL9831170 | 0.79 | KMT2A (0.59) | ALDH1A1TSHRMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL9831632 | 0.79 | HSD17B2 (0.53) | HSD17B2ALDH1A1POLBTDP1TSHR | |
| SCHEMBL9831999 | 0.78 | KDM4E (0.68) | ALDH1A1POLBTDP1TSHRMAPK1 | |
| SCHEMBL9830759 | 0.78 | LMNA (0.47) | ALDH1A1POLBTSHRKDM4ESMN1; SMN2 | |
| SCHEMBL9829790 | 0.76 | ALDH1A1 (0.41) | ALDH1A1TSHRKDM4ENPC1RAB9A | |
| SCHEMBL9830524 | 0.75 | POLB (0.63) | ALDH1A1POLBTDP1TSHRKDM4E | |
| SCHEMBL14582858 | 0.75 | HSD17B2 (0.68) | HSD17B2ALDH1A1POLBTSHRMAPK1 | |
| SCHEMBL5161173 | 0.73 | HSD17B2 (0.66) | HSD17B2ALDH1A1POLBTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |